GMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the GMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, THOP1, and ANKRD13B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP biosynthetic process activity versus CSNK1G2 in STOMACH (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CSNK1G2 →	+1.356	+0.633	<.001	<.001	3	7
STOMACH	THOP1 →	+1.175	+0.653	<.001	.001	3	7
BONE	ANKRD13B →	+1.710	+0.400	.009	.008	3	7
BREAST	KATNB1 →	+0.789	+0.310	<.001	<.001	3	7
PANCREAS	RUVBL1 →	+0.862	+0.538	.001	<.001	3	7
BREAST	ARMC6 →	+0.939	+0.316	.007	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006177 vs CSNK1G2 — STOMACH

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