AMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the AMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A10, GATB, and ANKRD13B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP biosynthetic process activity versus SLC16A10 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC16A10 →	+1.261	+0.229	<.001	.007	3	7
LARGE_INTESTINE	GATB →	+0.534	+0.393	<.001	.005	3	7
STOMACH	ANKRD13B →	+1.474	+0.627	.004	.005	3	6
LARGE_INTESTINE	TXN2 →	+0.761	+0.620	<.001	.009	3	6
OVARY	RNF126 →	+0.554	+0.935	.003	.002	3	6
LIVER	RPA1 →	+0.905	+0.467	.003	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006167 vs SLC16A10 — BLOOD_Leukemia

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