Purine ribonucleoside salvage

Across TCGA patient cohorts, RNA activity of the Purine ribonucleoside salvage pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRTFDC1, SUPT16H, and DNAJC9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside salvage activity versus PRTFDC1 in BRCA (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRTFDC1 →	+0.729	+0.065	<.001	<.001	3	8
LUAD	SUPT16H →	+0.310	+0.069	<.001	<.001	3	7
BRCA	DNAJC9 →	+0.345	+0.038	<.001	<.001	3	7
LSCC	MCM2 →	+0.545	+0.069	.002	<.001	3	6
LUAD	MCM6 →	+0.743	+0.082	<.001	<.001	3	6
LUAD	MCM2_S139 →	+0.827	+0.060	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006166 vs PRTFDC1 — BRCA

Explore this scatter interactively →