Purine ribonucleoside salvage

Across TCGA patient cohorts, RNA activity of the Purine ribonucleoside salvage pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, TUBB8P1, and MTAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside salvage activity versus CDKN2A in LSCC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDKN2A →	+1.691	+0.114	<.001	<.001	3	4
HNSC	TUBB8P1 →	+0.919	+0.093	<.001	<.001	3	4
HNSC	MTAP →	+1.179	+0.105	<.001	<.001	3	4
LSCC	CDKN2B →	+0.982	+0.084	.001	<.001	3	3
LSCC	CDKN2B-AS1 →	+0.677	+0.091	.001	<.001	3	3
HNSC	ERVFRD-3 →	+0.580	+0.080	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006166 vs CDKN2A — LSCC

Explore this scatter interactively →