Purine nucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1, WAS, and LSP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside catabolic process activity versus SIPA1 in LUAD (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIPA1 →	+0.174	+0.048	.001	.001	3	7
HNSC	WAS →	+0.406	+0.069	.002	.004	3	7
HNSC	LSP1 →	+0.577	+0.088	<.001	<.001	3	6
GBM	APBB1IP →	+0.603	+0.083	<.001	<.001	3	6
HNSC	STK4 →	+0.361	+0.077	<.001	.001	3	5
HNSC	TBC1D1 →	+0.310	+0.093	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006152 vs SIPA1 — LUAD

Explore this scatter interactively →