Purine nucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIEF2, PNP, and GHR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside catabolic process activity versus MIEF2 in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MIEF2 →	-0.948	-1.437	.006	<.001	3	4
OVARY	PNP →	+1.569	+1.265	.002	.006	3	4
OVARY	GHR →	-1.521	-1.325	<.001	.002	3	4
OVARY	EPHX2 →	-1.651	-1.357	.005	<.001	2	5
BONE	PNKD →	-0.707	-2.037	.001	<.001	3	4
LIVER	UBL7 →	+0.815	+0.546	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006152 vs MIEF2 — LUNG_SCLC

Explore this scatter interactively →