"Mitochondrial electron transport, succinate to ubiquinone"

Across TCGA cell cohorts, RNA activity of the "Mitochondrial electron transport, succinate to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR5L, RMDN3, and EAF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRR5L grouped by "Mitochondrial electron transport, succinate to ubiquinone"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRR5L →	-1.693	-1.221	.004	.003	3	5
BREAST	RMDN3 →	+0.560	+0.710	.001	.003	3	4
BREAST	EAF2 →	+0.928	+0.710	<.001	.003	3	4
BREAST	ROBO3 →	-2.114	-0.915	<.001	.001	3	4
BREAST	FHL3 →	-1.260	-0.709	<.001	.003	3	4
BREAST	CMTM4 →	+0.983	+1.059	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRR5L by "Mitochondrial electron transport, succinate to ubiquinone" activity — KIDNEY

Explore this box plot interactively →