Oxidative phosphorylation

Across TCGA cell cohorts, RNA activity of the Oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENPP1, CASP1, and ARMC10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENPP1 grouped by Oxidative phosphorylation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ENPP1 →	-1.247	-0.412	.001	<.001	3	4
BREAST	CASP1 →	-2.035	-0.398	<.001	<.001	3	4
BLOOD_Lymphoma	ARMC10 →	+0.929	+0.493	.005	.003	3	4
STOMACH	FRMD6 →	-3.757	-0.264	<.001	.008	3	4
BLOOD_Leukemia	CNKSR3 →	+1.672	+0.330	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CPT1A →	+1.989	+0.519	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENPP1 by Oxidative phosphorylation activity — OVARY

Explore this box plot interactively →