Oxidative phosphorylation

Across TCGA cell cohorts, RNA activity of the Oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD2, TACC3, and WDHD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative phosphorylation activity versus NSD2 in BLOOD_Leukemia (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NSD2 →	-1.157	-0.384	<.001	<.001	3	6
LIVER	TACC3 →	-1.043	-0.295	.006	.009	3	5
LUNG_NSCLC_LUAD	WDHD1 →	-0.666	-0.219	.001	.002	3	5
BLOOD_Lymphoma	FOXN3 →	-1.703	-0.193	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATP6V0E1 →	+0.571	+0.192	.005	.002	3	5
STOMACH	RAB40C →	+1.218	+0.314	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006119 vs NSD2 — BLOOD_Leukemia

Explore this scatter interactively →