Regulation of carbohydrate metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of carbohydrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM204BP, C3orf14, and FOXP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate metabolic process activity versus FAM204BP in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM204BP →	+0.352	+0.510	.005	.002	3	2
COAD	C3orf14 →	+1.033	+0.575	.001	.008	3	1
COAD	FOXP1 →	-0.457	-0.472	.005	.001	3	1
COAD	ATP6V1B1 →	-0.060	-0.676	<.001	.008	3	1
COAD	CIB4 →	+0.150	+0.448	<.001	.005	3	1
COAD	OBSCN-AS1 →	+0.140	+0.332	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006109 vs FAM204BP — COAD

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