Malate metabolic process

Across TCGA cell cohorts, RNA activity of the Malate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUCLA2, VWA8, and UTP14C, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Malate metabolic process activity versus SUCLA2 in BREAST (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SUCLA2 →	+0.927	+0.204	<.001	.003	3	11
STOMACH	VWA8 →	+0.925	+0.223	.002	.002	3	7
BREAST	UTP14C →	+0.803	+0.184	.009	.005	3	5
OESOPHAGUS	INTS6 →	+0.555	+0.178	.007	.002	3	5
BONE	B4GALT2 →	-1.042	-0.226	<.001	.006	3	4
KIDNEY	DCUN1D1 →	-0.625	-0.184	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006108 vs SUCLA2 — BREAST

Explore this scatter interactively →