Oxaloacetate metabolic process

Across TCGA patient cohorts, RNA activity of the Oxaloacetate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS29, KRT8P9, and PITHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxaloacetate metabolic process activity versus RPS29 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS29 →	-0.393	-0.107	.008	<.001	3	4
BRCA	KRT8P9 →	-0.640	-0.144	.006	.008	3	4
BRCA	PITHD1 →	-0.399	-0.191	<.001	<.001	3	4
CCRCC	PROC →	+0.996	+0.167	<.001	<.001	3	3
CCRCC	POF1B →	+1.493	+0.156	.002	<.001	3	3
CCRCC	MAGED4B →	-0.011	-0.116	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006107 vs RPS29 — LUAD

Explore this scatter interactively →