Oxaloacetate metabolic process

Across TCGA cell cohorts, RNA activity of the Oxaloacetate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHFL, ZC3H12C, and PSME1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHFL grouped by Oxaloacetate metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SHFL →	-1.180	-0.761	<.001	.002	3	6
URINARY_TRACT	ZC3H12C →	-0.947	-1.954	.005	<.001	3	5
SKIN	PSME1 →	-0.980	-0.837	.001	.003	2	6
URINARY_TRACT	NMNAT2 →	-2.388	-1.433	.007	.001	3	4
LIVER	IFITM3 →	-1.383	-1.013	<.001	.002	3	4
STOMACH	FLT3LG →	-1.201	-0.868	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHFL by Oxaloacetate metabolic process activity — BREAST

Explore this box plot interactively →