Oxaloacetate metabolic process

Across TCGA cell cohorts, RNA activity of the Oxaloacetate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP23, TKFC, and FYCO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxaloacetate metabolic process activity versus ARHGAP23 in SKIN (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGAP23 →	-2.356	-0.432	<.001	<.001	3	8
LIVER	TKFC →	+1.859	+0.300	<.001	.008	3	6
SKIN	FYCO1 →	+0.898	+0.288	.006	.002	3	6
SKIN	APEH →	+0.917	+0.423	.001	<.001	3	6
SKIN	MCRIP2 →	+0.939	+0.360	<.001	.002	2	7
PANCREAS	MARS2 →	+0.991	+0.341	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006107 vs ARHGAP23 — SKIN

Explore this scatter interactively →