Succinate metabolic process

Across TCGA patient cohorts, RNA activity of the Succinate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH5A1, SDHAF2, and MRPL47, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinate metabolic process activity versus ALDH5A1 in HNSC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALDH5A1 →	+0.524	+0.075	<.001	<.001	3	9
LUAD	SDHAF2 →	+1.045	+0.063	<.001	<.001	3	8
OV	MRPL47 →	+0.270	+0.042	.002	<.001	3	7
CCRCC	PMPCB →	+0.174	+0.042	.002	.007	3	6
OV	MRPS5 →	+0.295	+0.040	<.001	.002	3	6
OV	MRPS7 →	+0.282	+0.039	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006105 vs ALDH5A1 — HNSC

Explore this scatter interactively →