2-oxoglutarate metabolic process

Across TCGA patient cohorts, RNA activity of the 2-oxoglutarate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHYH, MYO9B, and MCM4_S120, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 2-oxoglutarate metabolic process activity versus PHYH in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHYH →	+0.579	+0.073	.004	.002	2	9
GBM	MYO9B →	-0.338	-0.058	<.001	<.001	3	7
OV	MCM4_S120 →	+1.249	+0.057	<.001	<.001	3	6
LSCC	STK10 →	-0.356	-0.059	<.001	<.001	3	6
LSCC	CLUH →	+0.266	+0.053	.002	.001	3	6
LSCC	FYB1_S457 →	-0.705	-0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006103 vs PHYH — UCEC

Explore this scatter interactively →