2-oxoglutarate metabolic process

Across TCGA patient cohorts, RNA activity of the 2-oxoglutarate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, AKR7A3, and GPT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 2-oxoglutarate metabolic process activity versus RASAL3 in LUAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RASAL3 →	-0.627	-0.182	<.001	.001	3	6
LUAD	AKR7A3 →	+1.244	+0.162	<.001	<.001	3	6
LUAD	GPT2 →	+0.772	+0.164	<.001	<.001	3	6
PDAC	CD52 →	-0.490	-0.116	.009	.006	3	6
BRCA	TRAV26-1 →	-0.480	-0.117	.006	.007	3	5
OV	L2HGDH →	+0.501	+0.202	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006103 vs RASAL3 — LUAD

Explore this scatter interactively →