2-oxoglutarate metabolic process

Across TCGA cell cohorts, RNA activity of the 2-oxoglutarate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADPRS, ST3GAL3, and AVPI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADPRS grouped by 2-oxoglutarate metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADPRS →	-0.635	-0.398	<.001	.006	3	4
STOMACH	ST3GAL3 →	-1.595	-1.332	.003	.004	3	4
BLOOD_Lymphoma	AVPI1 →	+1.900	+0.498	.003	.005	3	3
LIVER	NUB1 →	-0.846	-1.599	.008	.003	3	3
BLOOD_Myeloma	LDLRAD4 →	+1.336	+0.318	<.001	.001	3	3
OVARY	NUP88 →	+0.654	+0.817	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADPRS by 2-oxoglutarate metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →