2-oxoglutarate metabolic process

Across TCGA cell cohorts, RNA activity of the 2-oxoglutarate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPT2, IDH1, and PHYH, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 2-oxoglutarate metabolic process activity versus GPT2 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPT2 →	+1.676	+0.074	<.001	<.001	3	15
LIVER	IDH1 →	+1.678	+0.126	.002	.002	2	14
OESOPHAGUS	PHYH →	+1.621	+0.120	<.001	.004	3	13
OVARY	EPB41 →	+1.108	+0.096	.002	.006	3	12
OESOPHAGUS	IDH2 →	+1.623	+0.149	<.001	<.001	3	11
STOMACH	IKBIP →	-1.560	-0.145	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006103 vs GPT2 — BLOOD_Leukemia

Explore this scatter interactively →