2-oxoglutarate metabolic process

Across TCGA cell cohorts, RNA activity of the 2-oxoglutarate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPFIBP2, BCL11A, and ATP5MC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 2-oxoglutarate metabolic process activity versus PPFIBP2 in STOMACH (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPFIBP2 →	+3.391	+0.403	<.001	.002	3	6
LARGE_INTESTINE	BCL11A →	+1.996	+0.182	<.001	.004	3	5
BONE	ATP5MC3 →	+0.954	+0.277	<.001	.002	3	5
STOMACH	RETSAT →	+1.824	+0.366	.001	.004	3	5
URINARY_TRACT	MECOM →	+2.452	+0.363	.009	<.001	2	5
LIVER	MRPS11 →	+0.972	+0.309	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006103 vs PPFIBP2 — STOMACH

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