Isocitrate metabolic process

Across TCGA patient cohorts, RNA activity of the Isocitrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IDH3G, ACO2, and IDH3B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isocitrate metabolic process activity versus IDH3G in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IDH3G →	+0.395	+0.061	<.001	<.001	3	7
OV	ACO2 →	+0.486	+0.045	<.001	.004	3	6
LSCC	IDH3B →	+0.494	+0.066	<.001	<.001	3	6
GBM	GOT1 →	+0.479	+0.038	.001	.001	3	6
BRCA	TOMM70 →	+0.296	+0.033	<.001	<.001	3	6
GBM	TGFBI →	-0.639	-0.041	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006102 vs IDH3G — OV

Explore this scatter interactively →