Acetyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGAM1_S31, SEPTIN4, and SEPTIN4_S432, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process activity versus PGAM1_S31 in HNSC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGAM1_S31 →	-0.592	-0.093	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.671	+0.064	<.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.970	+0.075	<.001	<.001	3	7
BRCA	SPTBN1_S257 →	+0.809	+0.038	<.001	.004	3	7
GBM	ASPA →	+0.913	+0.069	<.001	<.001	3	7
GBM	SEPTIN4_S117 →	+0.808	+0.050	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006085 vs PGAM1_S31 — HNSC

Explore this scatter interactively →