Acetyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM3, AFAP1L2, and CLMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process activity versus CMTM3 in BRCA (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMTM3 →	-0.487	-0.100	.001	.001	3	4
OV	AFAP1L2 →	-1.332	-0.165	.006	.008	3	4
BRCA	CLMP →	-0.679	-0.142	.004	<.001	3	4
LSCC	GAS1 →	-0.735	-0.147	.007	.009	3	4
CCRCC	IMPA2 →	+0.701	+0.189	.009	.009	3	3
CCRCC	VMO1 →	-0.642	-0.291	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006085 vs CMTM3 — BRCA

Explore this scatter interactively →