Acetyl-CoA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Acetyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLAT, DDB2, and CCNC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process activity versus DLAT in LUNG_SCLC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DLAT →	+0.890	+0.227	.008	<.001	2	7
BLOOD_Lymphoma	DDB2 →	-1.043	-0.125	.003	.008	3	5
UPPER_AERODIGESTIVE_TRACT	CCNC →	+0.889	+0.212	.005	.002	3	5
BLOOD_Myeloma	MAPKAPK2 →	-1.636	-0.204	.003	.001	3	4
LUNG_SCLC	LHFPL2 →	-1.313	-0.199	.001	.004	2	5
UPPER_AERODIGESTIVE_TRACT	PGAM5 →	+0.847	+0.162	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006085 vs DLAT — LUNG_SCLC

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