Cellular aldehyde metabolic process

Across TCGA cell cohorts, RNA activity of the Cellular aldehyde metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP2, ANLN, and DYSF, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular aldehyde metabolic process activity versus LTBP2 in PANCREAS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LTBP2 →	-1.754	-0.248	<.001	<.001	2	7
BONE	ANLN →	-1.267	-0.291	<.001	.008	3	6
SOFT_TISSUE	DYSF →	-3.185	-0.262	<.001	<.001	3	6
OVARY	SERPINE1 →	-4.631	-0.257	<.001	<.001	3	6
BREAST	ETS1 →	-3.032	-0.199	<.001	.001	3	6
BREAST	GPD1L →	+1.816	+0.252	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006081 vs LTBP2 — PANCREAS

Explore this scatter interactively →