Ethanol metabolic process

Across TCGA patient cohorts, RNA activity of the Ethanol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACSS1, ADH1C, and ALDH2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ethanol metabolic process activity versus ACSS1 in PDAC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ACSS1 →	+0.671	+0.121	<.001	<.001	3	8
COAD	ADH1C →	+1.055	+0.058	<.001	<.001	3	7
OV	ALDH2 →	+0.972	+0.081	<.001	<.001	3	7
LUAD	GPD1L →	+0.466	+0.094	.002	<.001	3	7
UCEC	TTC39A →	+0.648	+0.087	<.001	<.001	2	7
PDAC	MYO9B_S1290 →	-0.660	-0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006067 vs ACSS1 — PDAC

Explore this scatter interactively →