N-acetylglucosamine metabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylglucosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UAP1L1, HMGA1P8, and LAMTOR3P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylglucosamine metabolic process activity versus UAP1L1 in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UAP1L1 →	+0.511	+0.145	<.001	<.001	3	4
COAD	HMGA1P8 →	+0.338	+0.165	.002	.001	3	4
OV	LAMTOR3P2 →	+0.420	+0.187	<.001	.001	3	3
PDAC	SAP18 →	+0.211	+0.113	.007	.006	3	3
PDAC	BTBD7P1 →	+0.390	+0.110	.001	.001	3	3
PDAC	RPS23P2 →	+0.222	+0.134	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006044 vs UAP1L1 — LUAD

Explore this scatter interactively →