Chitin metabolic process

Across TCGA patient cohorts, RNA activity of the Chitin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHI3L1, CHI3L2, and HSD11B1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chitin metabolic process activity versus CHI3L1 in TGCT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	CHI3L1 →	+4.105	+0.122	<.001	<.001	3	29
LGG	CHI3L2 →	+2.290	+0.081	<.001	<.001	3	22
DLBC	HSD11B1 →	+2.912	+0.140	<.001	.001	3	21
TGCT	PTGDS →	+3.692	+0.119	<.001	<.001	3	19
SCLC	C3 →	+2.265	+0.919	<.001	<.001	3	19
TGCT	IGSF6 →	+2.541	+0.136	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006030 vs CHI3L1 — TGCT

Explore this scatter interactively →