Chitin metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Chitin metabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Chitin metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCEC, show the opposite pattern, with higher activity associated with better survival.

LGG, LUAD, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.656	0.809	<.001	52	view →
LUAD	OS	Quartile	All	0.748	0.603	.004	44	view →
UCEC	OS	Median	All	0.952	0.901	.004	42	view →
ESCA	DFS	Median	II,III,IV	0.626	0.427	.003	42	view →
KIRC	DFS	Tertile	All	0.502	0.716	<.001	40	view →
KIRP	OS	Median	All	0.977	0.889	<.001	36	view →
PRAD	DFS	Median	All	0.959	0.909	.010	18	view →
GBM	DFS	Tertile	All	0.201	0.411	.007	12	view →
LUSC	DFS	Median	III,IV	0.439	0.206	.015	10	view →
SKCM	OS	Median	IV	0.651	0.186	.027	10	view →
MESO	OS	Quartile	All	0.501	0.258	.012	6	view →
CHOL	DFS	Median	II,III,IV	0.606	0.131	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0006030–LGG (DFS)

Open the LGG breakdown →