Chitin metabolic process

Across TCGA patient cohorts, RNA activity of the Chitin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2_T593, DOCK2, and EVI2B_S268, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chitin metabolic process activity versus THEMIS2_T593 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	THEMIS2_T593 →	+0.682	+0.129	<.001	<.001	3	7
LSCC	DOCK2 →	+0.658	+0.099	<.001	<.001	3	7
BRCA	EVI2B_S268 →	+0.892	+0.083	<.001	<.001	3	7
GBM	ALOX5 →	+0.654	+0.127	<.001	<.001	3	7
GBM	HCLS1 →	+0.630	+0.133	<.001	<.001	3	7
BRCA	ITGAL →	+0.738	+0.075	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006030 vs THEMIS2_T593 — GBM

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