Glycosaminoglycan catabolic process

Across TCGA patient cohorts, RNA activity of the Glycosaminoglycan catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF4B, SULF1, and PRKDC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosaminoglycan catabolic process activity versus PRPF4B in OV (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRPF4B →	-0.326	-0.039	<.001	.002	3	6
BRCA	SULF1 →	+0.612	+0.024	<.001	.008	3	5
COAD	PRKDC →	-0.238	-0.023	.003	.004	3	5
LUAD	MAP1B_T1282 →	+0.590	+0.030	.007	.002	2	6
CCRCC	VSIG4 →	+0.579	+0.035	.002	.001	3	5
BRCA	DDX17 →	-0.170	-0.031	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006027 vs PRPF4B — OV

Explore this scatter interactively →