Glycosaminoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosaminoglycan catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, SNAI3, and PA2G4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC1 grouped by Glycosaminoglycan catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAC1 →	+0.261	+0.106	.007	.005	3	7
LUNG_NSCLC_LUSC	SNAI3 →	-0.240	-0.115	.002	.005	3	6
LUNG_NSCLC_LUSC	PA2G4 →	-0.168	-0.128	.009	.007	3	6
BLOOD_Leukemia	SRP9 →	+0.250	+0.145	<.001	<.001	3	5
LUNG_SCLC	CPA6 →	-0.310	-0.154	.005	.006	3	5
CNS	PROCR →	-0.264	-0.196	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC1 by Glycosaminoglycan catabolic process activity — BREAST

Explore this box plot interactively →