Glycosaminoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosaminoglycan catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEXA, HEXB, and GNS, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosaminoglycan catabolic process activity versus HEXA in PANCREAS (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HEXA →	+2.153	+0.499	<.001	<.001	3	17
SOFT_TISSUE	HEXB →	+2.127	+0.755	<.001	.004	3	16
BLOOD_Lymphoma	GNS →	+1.301	+1.300	<.001	<.001	3	11
KIDNEY	PLBD2 →	+1.342	+0.292	.004	.009	1	12
SOFT_TISSUE	TPP1 →	+1.440	+0.565	<.001	.001	3	10
BLOOD_Leukemia	CTSA →	+1.139	+0.917	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006027 vs HEXA — PANCREAS

Explore this scatter interactively →