Aminoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRP9, NME6, and RAB17, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRP9 grouped by Aminoglycan catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SRP9 →	+0.257	+0.144	<.001	.001	3	7
LIVER	NME6 →	-0.250	-0.211	<.001	.002	3	6
LUNG_SCLC	RAB17 →	-0.270	-0.155	.004	.001	3	5
OESOPHAGUS	RAC1 →	+0.284	+0.128	.004	.002	3	5
BREAST	TEAD1 →	+0.282	+0.109	.002	.004	2	6
BONE	UFC1 →	+0.346	+0.325	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRP9 by Aminoglycan catabolic process activity — OESOPHAGUS

Explore this box plot interactively →