Aminoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK7, BLOC1S5-TXNDC5, and TBC1D10C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK7 grouped by Aminoglycan metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NEK7 →	-0.309	-1.056	.002	.003	3	5
OVARY	BLOC1S5-TXNDC5 →	-0.120	-0.750	.009	.004	3	5
LUNG_SCLC	TBC1D10C →	-0.264	-1.295	.008	.003	3	4
LUNG_SCLC	SLC28A3 →	-0.236	-1.062	.002	.002	2	5
BONE	CAMKK1 →	-0.543	-1.102	<.001	.003	3	4
SOFT_TISSUE	ABCC5 →	-0.338	-1.247	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK7 by Aminoglycan metabolic process activity — OVARY

Explore this box plot interactively →