Galactose metabolic process

Across TCGA patient cohorts, RNA activity of the Galactose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLS2, ECE1, and ITGB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose metabolic process activity versus GLS2 in LSCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GLS2 →	-0.177	-0.103	<.001	<.001	3	4
LUAD	ECE1 →	+0.406	+0.087	.005	.006	3	4
GBM	ITGB3 →	+0.811	+0.137	<.001	.003	3	4
HNSC	SNORA5C →	-0.984	-0.126	.003	.005	3	4
GBM	B4GALT1 →	+0.708	+0.179	<.001	<.001	3	4
BRCA	XXYLT1-AS1 →	-0.157	-0.134	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006012 vs GLS2 — LSCC

Explore this scatter interactively →