Galactose metabolic process

Across TCGA cell cohorts, RNA activity of the Galactose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGA2, MEI1, and AAMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGA2 grouped by Galactose metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GGA2 →	+0.970	+1.240	.001	<.001	3	4
KIDNEY	MEI1 →	-0.634	-1.101	.003	.006	3	4
LUNG_NSCLC_LUAD	AAMP →	+0.489	+0.915	<.001	.004	3	3
LUNG_NSCLC_LUAD	GADD45G →	+1.438	+0.859	.001	.002	3	3
LUNG_NSCLC_LUAD	ADAMTS16 →	-1.212	-0.916	<.001	.001	3	3
LUNG_NSCLC_LUAD	FLVCR1 →	+0.527	+0.845	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGA2 by Galactose metabolic process activity — CNS

Explore this box plot interactively →