Galactose metabolic process

Across TCGA cell cohorts, RNA activity of the Galactose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, STT3B, and IER3IP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose metabolic process activity versus GLB1 in SKIN (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GLB1 →	+0.676	+0.964	.003	.009	3	5
SKIN	STT3B →	+0.564	+1.129	.008	.002	3	4
LUNG_NSCLC_LUAD	IER3IP1 →	+0.480	+0.799	.003	<.001	3	4
LARGE_INTESTINE	SYCP2L →	-0.412	-1.163	.007	.002	3	4
BLOOD_Lymphoma	SYNJ1 →	+0.601	+0.670	.003	.005	3	4
OVARY	TMEM115 →	+0.493	+0.945	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006012 vs GLB1 — SKIN

Explore this scatter interactively →