Glucose metabolic process

Across TCGA patient cohorts, RNA activity of the Glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT80, MYADML2, and MRS2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose metabolic process activity versus KRT80 in COAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KRT80 →	-0.824	-0.157	.001	.001	3	2
COAD	MYADML2 →	+0.847	+0.171	<.001	.006	3	2
OV	MRS2 →	-0.810	-0.116	.007	.007	2	2
OV	PPP1R14BP2 →	-3.796	-0.116	<.001	.007	2	2
OV	RNASEH1P2 →	-1.403	-0.116	.009	.007	2	2
COAD	SNX25 →	-0.615	-0.253	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006006 vs KRT80 — COAD

Explore this scatter interactively →