Glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, RPS6KA5, and STUB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose metabolic process activity versus FAH in CNS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAH →	+0.629	+0.156	.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	RPS6KA5 →	+0.904	+0.221	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	STUB1 →	+0.671	+0.236	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CLPX →	+0.643	+0.244	.002	<.001	3	5
STOMACH	DHRS4L2 →	+1.202	+0.298	<.001	<.001	3	5
KIDNEY	COL17A1 →	-0.719	-0.238	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006006 vs FAH — CNS

Explore this scatter interactively →