Polysaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, SPARCL1, and SYNPO2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide metabolic process activity versus CNN1 in LUAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CNN1 →	+0.667	+0.146	.002	<.001	3	7
BRCA	SPARCL1 →	+1.258	+0.245	<.001	.003	3	6
BRCA	SYNPO2 →	+0.751	+0.199	.002	.003	3	6
GBM	ANO6 →	+0.623	+0.293	<.001	.001	3	5
UCEC	SORBS1 →	+1.240	+0.196	<.001	.001	3	5
LUAD	F10 →	+0.792	+0.223	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005976 vs CNN1 — LUAD

Explore this scatter interactively →