Detection of calcium ion

Across TCGA patient cohorts, RNA activity of the Detection of calcium ion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, TLN1, and EFEMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of calcium ion activity versus ZYX in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZYX →	-0.397	-0.075	<.001	.003	3	8
BRCA	TLN1 →	-0.278	-0.077	<.001	<.001	3	7
CCRCC	EFEMP2 →	-0.669	-0.056	.003	.002	3	7
COAD	FERMT2 →	-0.512	-0.071	<.001	<.001	3	7
BRCA	CCDC80 →	-0.625	-0.063	<.001	<.001	3	7
BRCA	SPARCL1_S295 →	-0.815	-0.049	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005513 vs ZYX — GBM

Explore this scatter interactively →