Detection of calcium ion

Across TCGA patient cohorts, RNA activity of the Detection of calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, ELF3-AS1, and PZP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of calcium ion activity versus STIM1 in LSCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STIM1 →	+0.635	+0.317	<.001	<.001	2	5
COAD	ELF3-AS1 →	-0.465	-0.621	.008	.008	3	3
LUAD	PZP →	-0.414	-0.154	.002	.006	3	3
CCRCC	AGAP12P →	+0.929	+0.584	<.001	.003	3	3
UCEC	GASK1B →	+1.132	+0.384	<.001	.008	3	3
LUAD	DNAJC12 →	+0.932	+0.182	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005513 vs STIM1 — LSCC

Explore this scatter interactively →