Detection of calcium ion

Across TCGA cell cohorts, RNA activity of the Detection of calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAPLN3, TMEM120B, and TRPC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAPLN3 grouped by Detection of calcium ion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HAPLN3 →	+1.445	+1.116	.007	.005	3	3
OESOPHAGUS	TMEM120B →	+0.660	+0.822	<.001	.007	3	3
PANCREAS	TRPC1 →	+1.201	+0.848	<.001	<.001	3	3
CNS	FAAP24 →	+0.573	+0.469	.001	.004	3	3
CNS	MAPK11 →	+0.894	+0.440	.001	.007	3	3
CNS	PRR19 →	+0.533	+0.479	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HAPLN3 by Detection of calcium ion activity — OESOPHAGUS

Explore this box plot interactively →