Detection of calcium ion

Across TCGA cell cohorts, RNA activity of the Detection of calcium ion pathway is significantly associated with the protein abundance of multiple proteins, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STIM1, MDH1, and SERBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of calcium ion activity versus STIM1 in CNS (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STIM1 →	+1.058	+0.270	.001	.002	3	8
LARGE_INTESTINE	MDH1 →	-4.463	-0.517	.004	.005	3	5
LARGE_INTESTINE	SERBP1 →	-3.086	-0.517	.005	.005	3	5
CNS	PAPSS1 →	-1.056	-0.290	.003	<.001	3	4
CNS	KHSRP →	-0.668	-0.290	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZC3H15 →	-1.550	-0.322	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005513 vs STIM1 — CNS

Explore this scatter interactively →