Growth plate cartilage development

Across TCGA patient cohorts, RNA activity of the Growth plate cartilage development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, VCL, and FLNA, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth plate cartilage development activity versus TIMP2 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP2 →	+0.696	+0.099	<.001	<.001	3	10
COAD	VCL →	+0.342	+0.037	.006	.005	3	10
BRCA	FLNA →	+0.431	+0.040	<.001	.001	3	10
PDAC	ISLR →	+0.756	+0.058	<.001	.001	3	10
CCRCC	PALLD →	+0.626	+0.038	.002	.009	3	10
BRCA	PCOLCE →	+0.712	+0.059	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003417 vs TIMP2 — OV

Explore this scatter interactively →