Growth plate cartilage development

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXJ3, ARID4B, and KDM4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXJ3 grouped by Growth plate cartilage development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FOXJ3 →	+0.871	+0.273	<.001	.004	3	4
LUNG_SCLC	ARID4B →	+0.993	+0.430	<.001	.007	3	4
LUNG_SCLC	KDM4A →	+1.246	+0.511	.001	<.001	3	4
BLOOD_Leukemia	ZNF800 →	+0.705	+1.111	.004	.001	3	4
LARGE_INTESTINE	CCDC186 →	+0.821	+0.857	.002	.002	3	4
BLOOD_Myeloma	RAB6A →	+0.724	+0.353	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXJ3 by Growth plate cartilage development activity — LUNG_SCLC

Explore this box plot interactively →