Growth plate cartilage development

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LXN, FAM214B, and SLC25A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth plate cartilage development activity versus LXN in SKIN (Pearson r = -0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LXN →	-6.010	-0.452	.001	.007	3	3
BLOOD_Leukemia	FAM214B →	-1.271	-0.946	.004	.004	3	3
OESOPHAGUS	SLC25A1 →	-1.064	-1.550	.007	.002	3	3
LUNG_NSCLC_LUSC	CYBB →	-0.109	-1.962	.008	.005	3	3
CNS	PINLYP →	+3.180	+1.648	.002	<.001	3	3
PANCREAS	ITIH6 →	+0.066	+1.812	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003417 vs LXN — SKIN

Explore this scatter interactively →