Neural retina development

Across TCGA cell cohorts, RNA activity of the Neural retina development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLTP, ALAS1, and TMEM38A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural retina development activity versus PLTP in OVARY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLTP →	+3.329	+0.346	<.001	<.001	3	4
BLOOD_Leukemia	ALAS1 →	-0.793	-0.229	.004	.007	3	4
BLOOD_Leukemia	TMEM38A →	-0.955	-0.217	<.001	.002	3	4
OESOPHAGUS	MOCS3 →	+0.885	+0.285	.003	.006	3	4
LUNG_NSCLC_LUSC	FURIN →	-1.780	-0.280	.009	.001	3	4
LUNG_NSCLC_LUSC	PLEKHM2 →	-0.922	-0.317	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003407 vs PLTP — OVARY

Explore this scatter interactively →