Retinal pigment epithelium development

Across TCGA patient cohorts, RNA activity of the Retinal pigment epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBQLN4, UTP20, and DDX54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal pigment epithelium development activity versus UBQLN4 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBQLN4 →	+0.505	+0.418	.001	.004	3	4
LUAD	UTP20 →	+0.375	+0.432	.002	.003	3	4
LUAD	DDX54 →	+0.331	+0.718	.008	<.001	3	4
PDAC	RNU7-186P →	-0.880	-0.207	.005	.009	3	3
OV	CHRAC1 →	+0.578	+0.224	.005	.001	3	3
OV	WDR74 →	+0.382	+0.196	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003406 vs UBQLN4 — UCEC

Explore this scatter interactively →